Polyethylene glycol (PEG) is a synthetic ethylene oxide polymer with a repetitive structure of (O-CH2-CH2)n. In the 1970s Dr. Frank Davis reported the modification of a new recombinant protein with PEG with the goal of enhancing pharmacokinetics. The process of covalent coupling of PEG to another molecule including proteins, peptides, antibodies, and aptamers became known as PEGylation.
Several studies have been performed demonstrating the applicability of IgY in diagnostic virology where it can be used as a biological input in immunoassays. In the first outbreak of SARS-CoV, an immunoswab assay was developed to detect the SARS-CoV nucleocapsid protein of the virus and compared the use of an IgG monoclonal antibody (mAb) with a chicken IgY antibody.
Polyethylene glycol (PEG) is a synthetic ethylene oxide polymer with a repetitive structure of (O-CH2-CH2)n. In the 1970s Dr. Frank Davis reported the modification of a new recombinant protein with PEG with the goal of enhancing pharmacokinetics. The process of covalent coupling of PEG to another molecule including proteins, peptides, antibodies, and aptamers became known as PEGylation.
Several studies have been performed demonstrating the applicability of IgY in diagnostic virology where it can be used as a biological input in immunoassays. In the first outbreak of SARS-CoV, an immunoswab assay was developed to detect the SARS-CoV nucleocapsid protein of the virus and compared the use of an IgG monoclonal antibody (mAb) with a chicken IgY antibody.
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