Several studies have been performed demonstrating the applicability of IgY in diagnostic virology where it can be used as a biological input in immunoassays. In the first outbreak of SARS-CoV, an immunoswab assay was developed to detect the SARS-CoV nucleocapsid protein of the virus and compared the use of an IgG monoclonal antibody (mAb) with a chicken IgY antibody.