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Is the Use of Polyethylene Glycol a Catch-22?

Polyethylene glycol (PEG) is a synthetic ethylene oxide polymer with a repetitive structure of (O-CH2-CH2)n. In the 1970s Dr. Frank Davis reported the modification of a new recombinant protein with PEG with the goal of enhancing pharmacokinetics. The process of covalent coupling of PEG to another molecule including proteins, peptides, antibodies, and aptamers became known as PEGylation.

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One year later…dealing with SARS-CoV-2 variants

One year after the SARS-CoV-2 was declared a pandemic, over 110 million cases and 2.5 million deaths worldwide, unprecedented lockdowns, quarantines and economic devastation, several vaccine candidates have been approved by regulatory authorities. But what do the emergence of new SARS-CoV-2 mean for vaccination and the end of the global pandemic?

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How Chicken Polyclonal Antibodies Can Solve a Global Pandemic

Several studies have been performed demonstrating the applicability of IgY in diagnostic virology where it can be used as a biological input in immunoassays. In the first outbreak of SARS-CoV, an immunoswab assay was developed to detect the SARS-CoV nucleocapsid protein of the virus and compared the use of an IgG monoclonal antibody (mAb) with a chicken IgY antibody.

Continue Reading >>

Is the Use of Polyethylene Glycol a Catch-22?

Polyethylene glycol (PEG) is a synthetic ethylene oxide polymer with a repetitive structure of (O-CH2-CH2)n. In the 1970s Dr. Frank Davis reported the modification of a new recombinant protein with PEG with the goal of enhancing pharmacokinetics. The process of covalent coupling of PEG to another molecule including proteins, peptides, antibodies, and aptamers became known as PEGylation.

Continue Reading >>

One year later…dealing with SARS-CoV-2 variants

One year after the SARS-CoV-2 was declared a pandemic, over 110 million cases and 2.5 million deaths worldwide, unprecedented lockdowns, quarantines and economic devastation, several vaccine candidates have been approved by regulatory authorities. But what do the emergence of new SARS-CoV-2 mean for vaccination and the end of the global pandemic?

Continue Reading >>

How Chicken Polyclonal Antibodies Can Solve a Global Pandemic

Several studies have been performed demonstrating the applicability of IgY in diagnostic virology where it can be used as a biological input in immunoassays. In the first outbreak of SARS-CoV, an immunoswab assay was developed to detect the SARS-CoV nucleocapsid protein of the virus and compared the use of an IgG monoclonal antibody (mAb) with a chicken IgY antibody.

Continue Reading >>
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